SakaguchiLaboratoryDepartment of Systems MedicineProfessorMinoru S.H. KoDepartment of Organoid MedicineProfessorToshiro SatoThe Sakaguchi Laboratory was established at the Keio University School of Medicine to promote cutting-edge research and education which able to quickly respond to the needs and demands of society and the constantly evolving conditions in the fields of medicine and the life sciences.e Department of Systems Medicine was established in the spring of 2012 with the generous support of the Keio University Medical Science Fund. Our department applies systems thinking/approaches to a variety of biomedical problems. Aiming for applications in regenerative medicine, we study the dierentiation, aging, and rejuvenation of embryonic and tissue stem cells through the analysis of gene regulatory networks. Aiming for clinical diagnosis and treatment, we also develop information technology to integrate medical information, including biomedical images and genome information.e Department of Organoid Medicine was launched as a new department of the Sakaguchi Laboratory in November 2018 with the support of the Keio University Medical Science Fund. Organoid technology enabled us to propagate and dierentiate various tissue stem cells into 3D structures resembling original tissues. Organoids derived from human heathy and diseased tissues retain near-native tissue structures and functions, providing a promising direction in the investigation of disease pathogenesis and applications to the regenerative medicine. We endeavor to establish Organoid Medicine as a new framework that can integrate basic biology and clinical medicine.8
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