Prize Laureates（1996-2020）1996Stanley B. Prusiner (* 1997) Discovery of prions and prion diseasesShigetada NakanishiStudies on the molecular structure and function of glutamate receptors2007Brian J. Druker Development of a molecular-targeted therapy for chronic myelogenous leukemiaHiroaki MitsuyaDevelopment of anti-AIDS drugs2008Fred H. Gage Physiological roles of adult neurogenesis in mammalian brainShimon SakaguchiDiscovery of regulatory T cells and their roles in immunological diseases2009Jeffrey M. Friedman Discovery of leptin and study of its physiological functionsKenji KangawaDiscovery and clinical application of ghrelin and other novel bioactive peptides2010Jules A. Hoffmann (* 2011) Discovery of insect-innate immune system and Toll receptorShizuo AkiraElucidation of molecular mechanisms of innate immune response for microbes2011Philip A. BeachyIdentification of Hedgehog, a key molecule in development,and its medical applicationsKeiji TanakaDiscovery of proteasome and elucidation of its physiological functions2012Steven A. RosenbergDevelopment of effective immunotherapies for patients with cancerHiroyuki ManoDiscovery of a lung cancer oncogene EML4-ALK and development ofmolecular targeted therapy2013Victor R. AmbrosDiscovery of microRNAs as a new class of gene regulatorsShigekazu NagataMolecular mechanisms of apoptosis and its physiology2014Karl DeisserothThe realization of optogenetics, and elucidation of brain function at theneuronal network levelHiroshi Hamada Molecular and cellular mechanisms of left-right asymmetry2015Jeffrey I. GordonHuman gut microbiome and its impact on health and diseaseYoshinori Ohsumi (* 2016) Elucidation of molecular mechanism of autophagy2016Svante PääboMolecular elucidation of human originTasuku Honjo (* 2018) Identification of PD-1 and establishment of cancer immunotherapy principleby PD-1 blockade2017John E. DickIdentification of cancer stem cellsSeiji Ogawa Development of functional MRI2019Hans C. CleversWnt signaling in stem cells and organogenesisTadamitsu KishimotoIL-6: From molecule to medicine2018Feng ZhangDevelopment of CRISPR/Cas system in mammalian cells and applicationfor medical scienceMasashi Yanagisawa Elucidation of sleep control mechanisms and applications in drug discovery1997Robert A. WeinbergProto-oncogenes, tumor suppressor genes and cancerTadatsugu TaniguchiMolecular biology of cytokine systems1998Moses Judah FolkmanMolecular mechanisms of angiogenesisKatsuhiko MikoshibaMammalian neural induction and brain pattern formation1999Elizabeth Helen Blackburn (* 2009) Telomeres and telemeraseShinya Yoshikawa Three-dimensional structure of bovine heart cytochromec oxidase and relation with enzyme activity2000Arnold J. Levine p53 as a tumor suppressor gene and an important signaling moleculeinvolved in various cellular functionsYusuke Nakamura Elucidation of various genetic diseases through human genome analysis2001Tony HunterIdentification of Sr tyrosine kinase and functional study of cell growthand tumorgenesisMasatoshi Takeichi Discovery of cadherin and studies on the molecular mechanisms of cell-cell adhesion2002Barry J. Marshall (* 2005) Isolation and cultivation of Helicobacter pylori- pioneering work in diagnosisand treatmentKoichi Tanaka Establishment and development of the living-donor liver transplantation system2003Ronald M. EvansElucidation of the molecular mechanisms of nuclear receptors that linklipid-soluble hormones and vitamins to gene expressionYasushi Miyashita Cerebral mechanisms of cognitive memory2004Roger Y. Tsien (** 2008)Visualization and control of molecules within living cells2005Yoshinori FujiyoshiDevelopment of high-resolution electron cryo-microscopy for thedetermination of membrane protein structures2006Thomas A. Steitz (** 2009) Structural basis of large ribosomal subunit function and drug development (* Nobel laureate in Physiology or Medicine, year received) (** Nobel laureate in Chemistry, year received)KEIO UNIVERSITYMEDICAL SCIENCE FUND7
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