OverviewOverview 9 Our laboratory focuses on the biological and pathophysiological characterization of a G protein-coupled receptor (GPCR) that senses bicarbonate ions, a new frontier spotlighted by our recent discovery. Our research spans from in vitro compound screening to animal disease model studies. Going forward beyond that, we explore GPCR signal transduction from the perspective of acid-base balance to uncover its roles in cellular responses, physiological functions, and disease progression.Cardiovascular diseases such as heart failure and ischemic heart disease are on the rise in aging societies. Our research aims to elucidate disease mechanisms and develop novel therapies to extend healthy life expectancy by applying innovative analytical approaches. In addition to conventional biomedical research methods, we integrate interdisciplinary approaches, including bioinformatics to visualize complex biological systems and artificial image analysis. By visualizing pathological states at the cellular and tissue levels through AI image analysis and spatio-temporal single-cell analysis, we strive to develop innovative therapeutic strategies.University School of Medicine and Graduate School of Medicine to advance cutting-edge research and education in the fields of medicine and the life sciences.Under the “Shinkanrin Maru” project, which aims to foster the development of outstanding young researchers, five laboratories led by independent associate professors have been established since April 2025. intelligence (AI)-driven Associate ProfessorAssociate ProfessorAiri Jo-WatanabeDai KusumotoDepartment of Ion Signaling and ResponseDepartment of Biomedical Informatics and Molecular BiologySakaguchiLaboratory The Sakaguchi Laboratory was established at the Keio
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