II CALSCFUNDMEDIENCEKEIVERSITYOUNOverviewOverviewOverview The fertilized egg , a unique cell with totipotency—the ability to differentiate into all tissues and organs—remains largely unexplored in terms of its internal mechanisms. Our laboratory seeks to elucidate the molecular mechanisms of totipotency from an epigenetic perspective, advancing fundamental medical research to understand the essence of life. Additionally, we investigate epigenetic mechanisms specific to mammals, exploring how genomic imprinting was acquired during evolution.This laboratory focuses on elucidating the mechanisms of signal transduction across cell membranes, with a particular emphasis on G protein-coupled receptors (GPCRs), which serve as critical drug targets. Our goal is to clarify their three-dimensional structures and functions. By leveraging cryo-electron microscopy, a technique for rapidly determining protein structures, we visualize the interactions between signaling molecules or drugs and receptors. Furthermore, through next-generation sequencing, we aim to uncover previously unidentified interactions between substances and receptors, exploring these relationships from both structural and functional perspectives through innovative research.We aim to elucidate the pathogenesis of gastrointestinal diseases and develop novel therapeutic strategies through spatial, dynamic, and transcriptomic analyses at the single immune cell level. Using patient-derived samples and murine disease models, we comprehensively investigate immune cell behavior under pathological conditions by modulating factors such as the gut microbiota, dietary components, pharmacological interventions, and signaling molecules. Leveraging cutting-edge technologies including single-cell RNA sequencing, spatial transcriptomics, and in vivo imaging systems, we seek to achieve an integrated understanding of the spatial and temporal regulation of immune cells, with the ultimate goal of translating these insights into therapeuticAssociate ProfessorAssociate ProfessorAssociate ProfessorTsunetoshi NakataniWataru ShihoyaTomohisa Sujino10 Department of Epigenetics and Stem Cell BiologyDepartment of Signal ExplorationDepartment of Multidimensional Analysis of Gastrointestinal Biology
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